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FILE - In this Sept. 23, 2011, file photo, President Barack Obama speaks about No Child Left Behind Reform in the East Room of the White House in Washington. In its initial review of No Child Left Behind waiver requests, the U.S. Department of Education highlighted a similar weakness in nearly every application: States did not do enough to ensure schools would be held accountable for the performance of all students. The Obama administration praised the states for their high academic standards. But nearly every application was critiqued for being loose on setting high goals and, when necessary, interventions, for all student groups _ including minorities, the disabled and low-income _ or failing to create sufficient incentives to close the achievement gap. (AP Photo/Charles Dharapak, File)
FILE - In this Sept. 23, 2011, file photo, President Barack Obama speaks about No Child Left Behind Reform in the East Room of the White House in Washington. In its initial review of No Child Left Behind waiver requests, the U.S. Department of Education highlighted a similar weakness in nearly every application: States did not do enough to ensure schools would be held accountable for the performance of all students. The Obama administration praised the states for their high academic standards. But nearly every application was critiqued for being loose on setting high goals and, when necessary, interventions, for all student groups _ including minorities, the disabled and low-income _ or failing to create sufficient incentives to close the achievement gap. (AP Photo/Charles Dharapak, File)
MIAMI (AP) ? In its initial review of No Child Left Behind waiver requests, the U.S. Education Department highlighted a similar weakness in nearly every application: States did not do enough to ensure schools would be held accountable for the performance of all students.
The Obama administration praised the states for their high academic standards. But nearly every application was criticized for being loose about setting high goals and, when necessary, interventions for all student groups ? including minorities, the disabled and low-income ? or for failing to create sufficient incentives to close the achievement gap.
Under No Child Left Behind, schools where even one group of students falls behind are considered out of compliance and subject to interventions. The law has been championed for helping shed light on education inequalities, but most now agree it is due for change.
Indiana's proposal to opt out of the federal law's strictest requirements was criticized by the Education Department for its "inattention" to certain groups, like students still learning the English language. New Mexico's plan, a panel of peer reviewers noted, did not include accountability and interventions for student subgroups based on factors like achievement and graduation rates. In Florida, the department expressed concern that the performance of some groups of students could go overlooked.
The concerns were outlined in letters sent last December by the administration to the 11 states that have applied for a waiver. Since then, state and federal officials have been talking about how to address the concerns; some states have already agreed to changes.
The letters were obtained by The Associated Press for all of the states except Tennessee and Kentucky, which declined to provide them until an announcement is made on whether a waiver is granted. The Education Department has previously said it expected to notify states by mid-January.
"Our priority is protecting children and maintaining a high bar even as we give states more flexibility to get more resources to the children most in need, even if that means the process takes a little longer than we anticipated," said Daren Briscoe, a department spokesman.
Jack Jennings, president of the Center on Education Policy, said federal officials are in a challenging spot.
"The current law means that each group of kids, whether they are children with a disability, or African-American, or poor kids, have attention paid to them, because the schools are accountable for each and every group," said Jennings. "But what the states are asking is that they all be lumped together."
The Bush-era law is aimed at making sure 100 percent of students reach proficiency in math and reading by 2014, a goal states are far from achieving. As that year draws closer, more and more schools are expected to fall out of compliance, subjecting them to penalties that range from after-school tutoring to closure.
While there is bipartisan agreement the 2002 law needs to be fixed, Congress has not passed a comprehensive reform. President Barack Obama announced in September that states could apply for waivers and scrap the proficiency requirement if they met conditions designed to better prepare and test students.
The 11 states that applied for the first round of waivers were Colorado, Florida, Georgia, Indiana, Kentucky, Oklahoma, Massachusetts, Minnesota, New Jersey, New Mexico and Tennessee. Many more states are expected to request waivers in the second round ? meaning all eyes will be on the first approvals.
The Center on Education Policy analyzed all the waiver requests and found that in nine of the 11 states, almost all decisions on penalties and interventions would be based on the performance of two groups: all students and a "disadvantaged" group that would replace the current system of separate categories of students according to race, ethnicity, income, disability and English language proficiency.
Those separate categories are at the heart of what No Child Left Behind aimed to correct ? vast achievement gaps between white, black and Hispanic students, between the affluent and low-income ? and what most agree is the problem with the law: If any one of these groups of students does not meet the state's annual benchmarks for proficiency in reading and math, the school is labeled as "failing."
In a letter sent Jan. 17, Sen. Tom Harkin, D-Iowa, and Rep. George Miller, D-Calif., urged Education Secretary Arne Duncan to require strong accountability measures and ensure civil rights and educational equity gains under No Child Left Behind are not lost.
"We fear that putting students with disabilities, English language learners and minority students into one 'super subgroup' will mask the individual needs of these distinct student subgroups," they said.
In the feedback provided to states by a panel of peer reviewers in December, many states were praised for plans to institute college and career-ready standards and develop teacher evaluation systems that take into account student growth ? two hallmarks of the Obama administration's education policy. The panel's concerns varied, but meeting the needs of all groups of students was one consistent theme.
In New Mexico, for example, the U.S. Education Department expressed concern about a lack of incentives to close achievement gaps and hold schools accountable for the performance of all students. In a follow-up letter sent late in January, subgroup accountability was still an area of concern.
Hanna Skandera, secretary designate for the New Mexico Public Education Department, said the state's original plan did include breaking down data on student performance by subgroup on each school's report card. But after conversations with the U.S. Education Department, schools will be adding information on whether they are on track for progress and growth in meeting annual targets. If a group falls behind, schools will be subject to intervention measures.
"We had high level reporting," Skandera said. "Now we're going to provide another layer so everything is crystal clear to parents across the state."
Minnesota's initial feedback included concern about "the lack of incentives to improve achievement for all groups of students and narrow achievement gap between subgroups." Sam Kramer, federal education policy specialist for the Minnesota Department of Education, said most of that criticism was focused on the state's graduation rate. In its initial submission, the state did not take into account the graduation rate of different subgroups in its annual targets.
After receiving the letter, the state switched to a system that will take into account how subgroups of students did in meeting those graduation targets.
Kramer said he thinks Minnesota will be better able to meet the needs of disadvantaged groups of students under the new system.
"No Child Left Behind was very good at diagnosing the problem," Kramer said. "It was very good at shining a light on the differences between subgroups."
It was less effective, he said, at offering successful ways to help improve.
"We are going to be able to go in and be flexible and reactive to the specific needs of those subgroups," Kramer said.
Pedro Noguera, an education professor at New York University, said the struggle by school districts to lift the performance of different groups of students is a signal of a deeper problem that won't be solved by waivers.
"We need to make sure the districts and schools feel some pressure to make sure that all the students they are responsible for are being educated," he said. "However, they need to focus on different kinds of evidence, and not merely performance on a standardized test. That's where they don't get it."
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Brown fat is hot, figuratively and perhaps literally. It is the focus of two recent research papers, one in mice and one in men, and the marquee item in a recent New York Times article, along with other media attention. Brown fat is hot, because it may help keep us warm, burn calories and help keep us thin.
But how hot is it? Proverbs tell us where there's smoke like this, there's fire. But sometimes where there's smoke, there's just smoke -- and a whole lot of hot air!
That was my impression when brown fat first started heating up in 2009. In the April 9 issue of the New England Journal of Medicine that year, three articles (1, 2, 3) and an editorial highlighted the potential, and apparently overlooked, importance of brown fat in human weight regulation.
I was surprised at that time that we were surprised to be learning that brown fat played a role in human temperature regulation and metabolism. I thought that we were taught just that in medical school (mid-1980s in my case). I somehow managed not to get the memo indicating that I didn't know what I thought I knew, and thus failed to be surprised in 2009.
Be that as it may, the New York Times jumped on the brown fat band-wagon then, suggesting that these "new" findings might offer a "cool way to lose weight" -- namely, by using some yet-to-be-discovered wonder drug to reset the human thermostat. Or, in the interim -- turning down the thermostat in our homes.
The heat has been turned up rather than down on the topic, however, with the advent of the two new brown fat studies. One, in mice, published in the prestigious journal Nature, purports to establish the existence of a new hormone, irisin, which is integral -- in exercising mice, at least -- to the process of converting garden-variety white fat into its hottie counterpart, brown fat. Irisin exists in humans as well as in rodents.
The excitement over this is summed up concisely by the authors:
Increased irisin levels in the blood cause an increase in energy expenditure in mice with no changes in movement or food intake. This results in improvements in obesity and glucose homeostasis. Irisin could be therapeutic for human metabolic disease and other disorders that are improved with exercise.
In other words, if irisin does in people just what it does in mice, and if we can develop irisin to give people, it might cause them to burn more calories without needing to exercise. Of course, amphetamines do that already -- and they're not really a terrific idea. But I don't want to get ahead of myself.
The second new study, and in some ways the more provocative of the two if only because the participants were human (six healthy men, to be exact), demonstrated that cold can induce brown fat to burn white fat. Body temperature is maintained with cold exposure by the combustion of the body's stored fuel (i.e., white fat) by the body's newly discovered (sort of) stove (i.e., brown fat). If the body gets even colder, shivering ensues -- and the muscle activity of shivering helps restore a normal temperature. Only when all of these defenses are overcome does hypothermia occur.
The new study was also noteworthy for the magnitude of the observed effect. By making the participants cold up to but not past the point of shivering, metabolic rate was reportedly increased by some 80 percent -- resulting in the expenditure of an extra 250 calories or so over 3 hours. That's not an unimpressive figure -- but a brisk walk for one hour would do the same.
That's why brown fat -- or at least brown fat combined with cold -- is hot.
One opportunity to which this research points is weight management by toughing out the cold. This seems to me a perfectly good and perfectly improbable recommendation. We already have good cause to turn our thermostats down and accept a nominal degree of perennial discomfort: We could save money, and help save the planet. Maybe the incentive of keeping last year's belt relevant this year will get us over the hump of habitual hypothermia -- but I'm thinking not. Being cold all the time is in, a word, uncomfortable. If people were willing to be uncomfortable to control weight, a whole lot more of us would exercise!
The second opportunity -- related in particular to the mouse study -- is to increase the generation of calorie-burning brown fat by exercising. But this is really just another way of saying if you exercise more, you are apt to weigh less -- and almost certain to be healthier. Those arguments haven't carried the day with most members of our population thus far, and it's not obvious that the added bonus of "and you'll have a bit more brown fat, too" will clinch the deal. In essence, this simply clarifies one mechanism by which exercise may do what we already know it does.
Which brings us to the last great opportunity: a new wonder drug. Irisin, or something like it, in a capsule or syringe.
I suppose we might devise a wonder drug for weight control -- and insights into the secret life of brown fat could be how we get there. But I am extremely dubious.
Insights into the secret life of our endocannabinoid system gave us rimonabant, the most promising weight control drug to come along in... just about forever. It causes weight loss, and improves a wide variety of metabolic parameters, too.
But it does so by tinkering with native neural pathways, and unintended consequences abound. For rimonabant, the most salient of those was a dramatic enough increase in the rate of suicide for the drug to be approved and then withdrawn in Europe, and never approved in the first place in the U.S.
I do not think we will find a drug to fix obesity. I invoke Nathaniel Hawthorne to help me make the case.
In Hawthorne's short story, "The Birthmark," a physician is married to a beautiful woman. She is, in fact, so beautiful that by all accounts, her beauty is nearly perfect. But her beauty is only NEARLY perfect. It is marred, ever so slightly, by a small birthmark on her cheek.
The physician hears so many times of his wife's "near perfect" beauty that he becomes seduced by the concept of perfect beauty. He thinks to himself: "After all, I'm a physician! I have the power -- I can do this."
Then the story slowly builds toward an ominous crescendo as the physician prepares an elixir and prepares his wife for a procedure. When at last all is ready, the physician stretches his wife out on a bed -- and administers his elixir to her. And lo and behold! The birthmark disappears, and her beauty is... flawless.
But, alas. Hawthorne was writing for the religious sensibilities of his time, and this story was a moral parable about the unattainable conceit of human perfection. And so this birthmark was no superficial blemish. Rather, it was the mark of the woman's inescapably imperfect humanity. The elixir removed the birthmark from her skin, but traced its remedial effects from her skin to the very core of her -- to her heart -- and rendered her beauty perfect... even as it killed her.
What the hell has this got to do with brown fat? More than you might think.
Like Hawthorne's hapless heroine, we, too, are "marked" by the fundamentals of the human condition. We are all offspring of predecessors who lived in a world where calories were relatively scarce and hard to get, and physical activity constant, arduous and unavoidable.
We now live in a world where physical activity is scarce and hard to get, and calories constant, effortless and unavoidable. Is it any wonder we have epidemic obesity?
But the solutions reside in fixing the havoc we have wrought in our environment and lifestyle, not tinkering with human metabolism. If we pollute the oceans and fish start to die off, a drug that will let fish live on land seems far less plausible than... cleaning up the oceans.
Do you recall the news flashes about obesity genes? Newly-discovered hormones that control hunger? Brown fat is the hot topic du jour.
We have numerous, intricate, overlapping layers of metabolic defense against starvation -- the threat that has stalked the heels of Homo sapiens from time immemorial. We have no native defenses against caloric excess because we never needed those before.
An effort to use a drug -- any drug -- to rework the fundamentals of human metabolism so that we don't turn a surplus of calories into an energy reserve in burgeoning adipose tissue seems to me an enterprise fraught with no less peril than Hawthorne's elixir. I don't believe we will ever devise such a drug -- and if ever we do, I shudder to think what its unintended consequences may be.
I am also tempted to wonder if I am the only one recollecting that obesity is now epidemic in CHILDREN. Are we thinking to use drugs to regulate the thermostats of growing children? Does anyone have even a clue what that might do to growth and development? As a parent, are you at all comfortable with the notion? The defense of doubt... rests.
Like everyone else, I hope the new studies of brown fat provide insights we may eventually exploit to improve the human condition. I am, I confess, a bit less inclined to give the whole topic the cold shoulder than I was in 2009.
But I am cool on the concept of weight control through pharmacology -- whether by beckoning to our brown fat, or by any other mechanism. Obesity is no superficial blemish to be medicated away; it's the birthmark of a people living in a world all too often at odds with the fundamentals of health, and certainly -- and profoundly -- at odds with healthful weight control. I contend, as I always have, that we will win or lose the war of weight control with our feet and our forks -- not pharmacotherapy.
So by all means, stay tuned to the smoke signals about brown fat. But I urge you to keep other irons in the fire.
-fin
For more by David Katz, M.D., click here.
For more on weight loss, click here.
For more on healthy living health news, click here.
Dr. David L. Katz; www.davidkatzmd.com
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ScienceDaily (Jan. 30, 2012) ? Stem cells derived from fat have a surprising trick up their sleeves: Encouraged to develop on a stiff surface, they undergo a remarkable transformation toward becoming mature muscle cells. The new research appears in the journal Biomaterials. The new cells remain intact and fused together even when transferred to an extremely stiff, bone-like surface, which has University of California, San Diego bioengineering professor Adam Engler and colleagues intrigued. These cells, they suggest, could hint at new therapeutic possibilities for muscular dystrophy.
In diseases like muscular dystrophy or a heart attack, ?muscle begins to die and undergoes its normal wounding processes,? said Engler, a bioengineering professor at the Jacobs School of Engineering at UC San Diego. ?This damaged tissue is fundamentally different from a mechanical perspective? than healthy tissue.
Transplanted stem cells might be able to replace and repair diseased muscle, but up to this point the transplants haven?t been very successful in muscular dystrophy patients, he noted. The cells tend to clump into hard nodules as they struggle to adapt to their new environment of thickened and damaged tissue.
Engler, postdoctoral scholar Yu Suk Choi and the rest of the team think their fat-derived stem cells might have a better chance for this kind of therapy, since the cells seem to thrive on a stiff and unyielding surface that mimics the damaged tissue found in people with MD.
In their study in the journal Biomaterials, the researchers compared the development of bone marrow stem cells and fat-derived stem cells grown on surfaces of varying stiffness, ranging from the softness of brain tissue to the hardness of bone.
Cells from the fat lineage were 40 to 50 times better than their bone marrow counterparts at displaying the proper proteins involved in becoming muscle. These proteins are also more likely to ?turn on? in the correct sequence in the fat-derived cells, Engler said.
Subtle differences in how these two types of cells interact with their environment are critical to their development, the scientists suggest. The fat-derived cells seem to sense their ?niche? on the surfaces more completely and quickly than marrow-derived cells. ?They are actively feeling their environment soon, which allows them to interpret the signals from the interaction of cell and environment that guide development,? Choi explained.
Perhaps most surprisingly, muscle cells grown from the fat stem cells fused together, forming myotubes to a degree never previously observed. Myotubes are a critical step in muscle development, and it?s a step forward that Engler and colleagues hadn?t seen before in the lab.
The fused cells stayed fused when they were transferred to a very stiff surface. ?These programmed cells are mature enough so that they don?t respond the environmental cues? in the new environment that might cause them to split apart, Engler says.
Engler and colleagues will now test how these new fused cells perform in mice with a version of muscular dystrophy. The cells survive in an environment of stiff tissue, but Engler cautions that there are other aspects of diseased tissue such as its shape and chemical composition to consider. ?From the perspective of translating this into a clinically viable therapy, we want to know what components of the environment provide the most important cues for these cells,? he said.
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RT @davewiner You want proof that Republicans are getting desperate. Here you go. http://t.co/GCZQAHSa
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By NBC News and msnbc.com staff
Authorities are investigating the death of a passenger aboard the Carnival Fantasy who fell from an upper deck to a lower deck while the cruise ship was docked in the Bahamas.
The 26-year-old victim, whose identity was not released, fell from one of the upper levels of the ship's atrium to the lobby level late Friday night, ?Carnival Cruise Lines said in a statement Saturday. The ship was docked in Nassau at the time.
Bahamas police said the man was from South Carolina and that initial reports indicate he may have jumped. He was pronounced dead at the scene.
The ship was cleared by authorities to sail Saturday morning,?but?because of the delay due to the investigation a?scheduled visit to Freeport was canceled.??????
Carnival Fantasy was sailing on a five-day Bahamas cruise that departed Charleston, S.C., on Wednesday and is scheduled to return to Charleston on Monday.
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AP
This citizen journalism image provided by the Local Coordination Committees in Syria purports to show anti-Syrian regime protesters during a demonstration in Idlib province, Syria Friday.
By NBC News and msnbc.com news services
Updated at 9:25 a.m. ET: The Arab League is in talks with Russia ahead of a meeting at the U.N. Security Council in New York to discuss the escalation of violence in Syria, the deputy secretary-general tells Reuters.
"There are ongoing talks and consultations between the Arab League and Russia over the Syria file," Ahmed Bin Hali says at the League in Cairo Saturday. "Yesterday there was a call between the Russian Foreign Minister Sergei Lavrov with Secretary-General Nabil el-Araby regarding the latest developments in the Syrian situation."
Updated at 8:30 a.m. ET: The Arab League's deputy chief says the observer mission to Syria has been halted because of violence, The Associated Press reports. An official tells NBC News that Arab foreign ministers will meet after the U.N. secretary general returns from the U.N. Security Council meeting to decide whether to withdraw monitors because of the violence.
Published at 7:30 a.m. ET: A Syrian opposition group claimed Saturday that 130 people had been killed across the country in just 24 hours by President Bashar al-Assad's forces.
The U.K.-based Syrian Observatory for Human Rights reported the death toll while speaking to NBC News in London.
Activists also told Reuters Saturday that the bodies of 17 men previously held by Syrian security forces have been found in the city of Hama.
"They were killed execution-style, mostly with one bullet to the head. Iron chains that had tied them were left on their legs as a message to the people to stop resisting," Abu al-Walid, an activist in the city, told Reuters by telephone.
NBC's Ayman Mohyeldin visits Zabadani, Syria, a once beautiful snowcapped resort town that has been deeply scarred by the recent military crackdown and speaks with members of the?anti-regime Free Syria Army.
Another activist said the bodies, their hands tied with plastic wire and some with their legs chained, were dumped in the streets of five Hama neighborhoods on Thursday evening.
Turkey was due to meet Gulf Arab states later Saturday to reinforce support for an Arab call for Assad to quit.
The Arab League and Western countries are pushing for a U.N. Security Council resolution on Syria, resisted by Assad's ally Russia. The U.N. Security Council discussed a new European-Arab draft resolution on Friday aimed at halting the bloodshed.??
The United Nations Children's Fund also said Friday that at least 384 children had been killed and virtually the same number had been jailed during the course of the uprising.
UN Security Council weights action on Syria
The U.N., which estimated in mid-December that more than 5,000 people had been killed, says it can no longer keep track of the total death toll. The Syrian government says insurgents have killed more than 2,000 soldiers and policemen.
'Siding with the Syrian people'
Turkey urged Syria's leadership to comply with an Arab League transition plan that calls on Assad to step down.
"We are siding with the Syrian people and their legitimate demands," Turkish President Abdullah Gul was quoted as saying by the United Arab Emirates newspaper al-Bayan.
Outside Syria capital, suburbs look like war zones
Turkish officials say the number of Syrians seeking sanctuary in Turkey has risen in the past six weeks, with 50 to 60 arriving daily, taking the total living in refugee camps to nearly 9,600 from about 7,000 previously.
More than 6,000 Syrian refugees have fled to Lebanon.
Turkey, which spent years rebuilding relations with Syria, turned against Assad after he ignored its advice to enact reforms to calm what began in March as a peaceful uprising against his rule, inspired by Arab revolts elsewhere.
Russia, which joined China in vetoing a previous Western draft U.N> resolution in October and which has since promoted its own draft, said the European-Arab version was unacceptable in its present form but added that it was willing to "engage" on it.
Russian U.N. Ambassador Vitaly Churkin criticized the draft, which endorses the Arab transition plan.
Moscow, he said, wants a Syrian-led political process, not "an Arab League-imposed outcome of a political process that has not yet taken place" or Libyan-style "regime change."
Reuters contributed to this report.
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LOS ANGELES (TheWrap.com) ? It was only two weeks ago that Twitter was protesting online censorship in the form of anti-piracy bills SOPA and PIPA. Now the social networking site faces a surge of opposition to its own censorship practices.
Twitter announced in a blog post Thursday that it will now block specific tweets on a country-by-country basis should the messages violate the laws of those countries.
One of the worries is that Twitter has been a powerful tool in the protest movements that have surfaced across the globe in the past year, whether in the Arab Spring or the anti-austerity protests in Europe.
The fear is that the new policy will limit its utility in such instances.
Users have responded by promising to boycott the site on Saturday, and the media has blasted the company for what it views as blatant censorship.
Forbes' writer Mark Gibbs dubbed the move "social suicide" and many others have chimed in to voice their objection.
The boycott of Twitter is being promulgated by the hashtag #TwitterBlackout -- not all that different from the #SOPABlackout tweets from earlier this month. In another case of overlap with the SOPA/PIPA fight, hacking network Anonymous seems to oppose the move. Not known yet is whether it will act.
It's doubtful that enough people will stop using the service to have an impact, nor would a brief Twitter shutdown damage its business. However, the threats are clearly more about sending a message than crippling the now ubiquitous messaging platform.
The site's reasoning for the change was stated in its blog post: "As we continue to grow internationally, we will enter countries that have different ideas about the contours of freedom of expression. Some differ so much from our ideas that we will not be able to exist there."
Observers see this as Twitter caving to the power of oppressive and restrictive foreign governments. They don't want to anger those countries too much, lest they block Twitter.
To some, this is appalling. To others, it's just business.
Either way, Twitter finds itself on the other end of the censorship fight for one of the first times.
Welcome to adulthood, Tweeps.
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No. Swiss banks have a history of dismissing applications originating in countries that have unusual tax regulations or a history of criminal economic activity. Such blacklists now tend to include the United States, on account of a federal law passed in 2010 called the Foreign Account Tax Compliance Act, which requires that Swiss banks submit sensitive information about their clients to the IRS, potentially violating Swiss privacy laws and imposing heavy costs of compliance. Those privacy laws are what make Swiss banks so attractive to foreign investors. (The country's stable economy and low rate of inflation are also plusses.) Romney closed his bank account in Zurich in 2010, the same year that that law was passed, although the lawyer who pulled the plug claims he did so because the account ?wasn?t serving any particular purpose.?
Source: http://feeds.slate.com/click.phdo?i=35692a596a6c474b8beaea8bcaa74dfb
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CAIRO (Reuters) ? Egyptians vote Sunday in the first stage of elections for the upper house of parliament, with Islamists seeking to repeat the success they enjoyed in elections for the lower house.
Voting for the Shura council will be held over two stages ending in the middle of February and follow a lower house election that was Egypt's most democratic since military officers overthrew the king in 1952.
The series of elections for both houses of parliament are the first since Hosni Mubarak was toppled from the presidency on February 11 last year by a popular uprising.
The Muslim Brotherhood, an Islamist group banned during his rule, won 47 percent of the seats in the lower house, more than any other party.
"The Shura council elections are as important as the People's Assembly (lower house) elections," said Hussein Ibrahim, a member of the Brotherhood's Freedom and Justice Party and head of its parliamentary bloc.
"Members of both chambers will choose the committee that will draft the constitution, the milestone of Egypt's democratic transition," he said.
Under an interim constitution, parliament is responsible for picking the 100-strong assembly that will write a new constitution to replace the one that helped keep Mubarak in power for three decades.
Elections for the Shura Council have traditionally been less intense than lower house due to the breadth of constituencies that makes it harder for voters to know their candidates.
The Shura chamber's powers are limited and it cannot block legislation in the lower house. However, its members must be consulted before lower house MPs pass any bill.
Ninety of the Shura council's 270 seats will be decided in the first round of voting to be held Sunday and Monday, with run-offs on February 7. Another 90 will be determined by voting on February 14 and 15, with run-offs on February 22.
The remaining 90 will be appointed by Egypt's next president, expected to be elected in June according a transition timetable drawn up by the military council to whom Mubarak handed power nearly a year ago.
"The elected part of the Shura council will convene without the appointed seats until presidential elections are held and the new president appoints the other 90 members," an official from the body overseeing the election told Reuters.
(Editing by Tom Perry and David Stamp)
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STATE COLLEGE, Pa (Reuters) ? The son of late Penn State football coach Joe Paterno told 10,000 mourners on Thursday his father died "with a clear conscience," and former players shared why they worshipped the man in a final goodbye to the legendary "JoePa."
The memorial at the campus basketball arena concluded five days of public mourning for Paterno, 85, who died on Sunday of lung cancer two months after his towering reputation was shaken by a child sexual abuse scandal involving an assistant coach.
The hero's sendoff after Paterno's death contrasted sharply with the sudden and unceremonious end of his career in November, when the university's board of trustees fired him following revelations about defensive coordinator Jerry Sandusky, accused of molesting at least 10 boys over 15 years.
Paterno won a major college record 409 games and two national championships in his 46 years as head coach, creating a football powerhouse that generated $53 million in profit in 2010, according to Forbes magazine.
Son Jay Paterno shared deathbed moments the crowd, saying, "Joe Paterno left this world with a clear conscience."
Shortly before his father died, Jay Paterno said he bent over and whispered into his father's ear, "Dad you won. You did all you could do. We all love you. You can go home."
Interest in "A Memorial to Joe" built for days. The 10,000 free tickets were snapped up within seven minutes earlier this week. At least one ticket holder tried to profit by selling a ticket for $66,000 on Ebay, but the online site immediately banned the sale.
The week of mourning has drawn back to campus stars from past football teams, members of the 2011 squad, Penn State alumni who have no memory of any other football coach, undergraduates and townspeople to remember the winningest coach in major college football history.
"No one individual did more for a university than what Joe Paterno did for this school," said Todd Blackledge, a quarterback in the 1980s who played for seven years in the NFL.
"He was as fierce a competitor as anyone I have ever seen," Blackledge said. "Coach Paterno was at his best under pressure. He taught us how to compete."
Charlie Pittman, a runningback from the 1960s, praised Paterno for building a long-lasting institution that prided itself on the motto "Success with Honor."
"Though his body eventually failed, his spirit never did. Rest in peace, coach. We'll take it from here," he said to a standing ovation.
Paterno came under fire in November when it was revealed he was told by a purported witness that Sandusky molested a 10-year-old boy in the Penn State football showers in 2002. Paterno informed university officials but not police.
Sandusky, 67, faces 52 criminal counts accusing him of molesting 10 boys over 15 years, using his position as head of The Second Mile, a charity dedicated to helping troubled children, to find his victims. The court has placed Sandusky, who maintains his innocence, under house arrest.
(Editing by Barbara Goldberg and Daniel Trotta)
Source: http://us.rd.yahoo.com/dailynews/rss/us/*http%3A//news.yahoo.com/s/nm/20120127/us_nm/us_usa_paterno
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(Reuters) ? Here are details of foreigners held by kidnappers around Africa. Two hostages were freed in Somalia by U.S. helicopters Wednesday.
* SOMALIA:
April 2008 - Gunmen seized a Briton and a Kenyan working on a U.N.-funded project.
July 14, 2009 - Somali gunmen kidnapped two French security advisers in Mogadishu. One of them, Marc Aubriere, escaped on August 26.
November 8, 2010 - The European Union anti-piracy task force said it had rescued a South African yachtsman after he was left behind by Somali pirates. Two other South African crew members were taken ashore as hostages.
October 25, 2011 - Three aid workers attached to the Danish Demining Group were kidnapped in the north of the country, the group said. One is a Somali man, two are international staff members, an American, Jessica Buchanan, and a Dane, Poul Thisted. The foreigners were freed on January 25 after a raid by U.S. forces who killed nine pirates and captured another five.
January 21, 2012 - Gunmen kidnapped an American near the Somali town of Galkayo in the semi-autonomous Galmudug region. Abshir Dini, interior minister of the semi-autonomous region, said his captors had taken him to Hobyo, a town that is a known pirate base.
* KENYA/SOMALIA:
September 11, 2011 - Gunmen raided the Kiwayu Safari Village, shooting dead British publishing executive David Tebbutt, escaping by boat taking his wife, Judith, with them to Somalia.
October 11, 2011 - Six armed men stormed a house on the island of Manda on Kenya's northern coast, grabbed 66-year-old wheelchair-bound Marie Dedieu and carried her to a boat that took her to Somalia. Paris said on October 19 that Dedieu had died.
October 13, 2011 - Two Spanish female aid workers employed by Medecins Sans Frontieres (MSF), Blanca Thiebaut and Montserrat Serra, were kidnapped at Kenya's Dadaab refugee camp near Somalia. They have since been moved to central Somalia.
* ETHIOPIA:
-- The rebel Afar Revolutionary Democratic Unity Front (ARDUF) claimed responsibility on January 21 for the kidnapping of two German tourists and two Ethiopians in an attack by gunmen in northern Ethiopia's remote Afar region on January 17.
-- Two Germans, one Austrian, and two Hungarians were killed in the same attack. One Hungarian was also wounded. Ethiopia said the victims were part of a 27-member party that also included U.S., Australian and Belgian nationals.
* MALI:
November 23, 2011 - Two French men, an engineer and a technician who work for a local cement firm were abducted from their hotel in the town of Hombori, about 200 km (125 miles) west of the northern city of Gao in northern Mali.
November 25, 2011 - Gunmen seized three people and killed a fourth on a street in the northern Mali town of Timbuktu. Those kidnapped were from South Africa, the Netherlands and Sweden.
-- Al Qaeda in the Islamic Maghreb (AQIM) claimed responsibility for both November kidnappings.
* ALGERIA:
February 2, 2011 - A 53-year-old Italian woman, Maria Sandra Mariani, was kidnapped by al Qaeda insurgents while on a tourist trip to the Sahara desert in southeastern Algeria.
October 23, 2011 - Three foreign workers were abducted from a refugee camp near Tindouf in western Algeria. The kidnappers had crossed from Mali.
-- Spain named the two as Ainhoa Fernandez de Rincon and Enric Gonyalons. The Italian was Rossella Urru.
* NIGERIA:
May 12, 2011 - Two engineers, a Briton and an Italian, working for Italian construction firm B. Stabilini in Kebbi State in northern Nigeria, were kidnapped in the town of Birnin-Kebbi.
* NIGER:
September 16, 2010 - Seven foreigners were kidnapped in Arlit, in Niger's northern uranium mining zone. AQIM claimed responsibility and demanded a 90 million euro ($130 million) ransom. Earlier in January the group threatened to kill its prisoners if France and its allies attacked its bases in Mali.
-- Some of the foreigners, including five French nationals, worked for French firms and were taken by their captors to Mali the next day.
February 25, 2011 - A Togolese, a Malagasy man and the French wife of one of the employees were freed and handed over to authorities in Niger.
Sources: Reuters/www.geopolicity.com
(Reporting by David Cutler, London Editorial Reference Unit)
(This January 25 story was corrected in the final item of the Somalia section to change the date of U.S. hostage kidnapping to Jan. 21 from Jan. 2)
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Tiger Woods from U.S. plays a ball on the 1st hole during the second round of Abu Dhabi HSBC Championship, Friday, Jan. 27, 2012, in Abu Dhabi, United Arab Emirates. (AP Photo/Kamran Jebreili)
Tiger Woods from U.S. plays a ball on the 1st hole during the second round of Abu Dhabi HSBC Championship, Friday, Jan. 27, 2012, in Abu Dhabi, United Arab Emirates. (AP Photo/Kamran Jebreili)
Tiger Woods from the U.S. plays a bunker shot on the 18th hole during the second round of the Abu Dhabi Golf Championship, in Abu Dhabi, United Arab Emirates, Friday, Jan. 27, 2012. (AP Photo/Kamran Jebreili)
Tiger Woods from U.S. tees off on the 1st hole during the second round of Abu Dhabi HSBC Championship, Friday, Jan. 27, 2012, in Abu Dhabi, United Arab Emirates. (AP Photo/Kamran Jebreili)
ABU DHABI, United Arab Emirates (AP) ? Tiger Woods moved into contention in the second round of the Abu Dhabi Golf Championship with a 3-under 69 Friday, two shots behind leader Thorbjorn Olesen of Denmark.
Woods had three straight birdies on the back nine to finish with a two-round total of 139.
Woods, who was three shots back after the first round, started slowly before making three birdies over five holes. He dropped a shot on the 16th after an errant drive landed in deep rough.
"I thought I played well today," Woods said. "I made a couple putts here and there, but it was tough out there. The greens got a little quicker, a little bit drier and the rough is certainly getting deeper and more lush."
Olesen (67) has a one-shot lead over two players, including 18-year-old Italian Matteo Manassero (65). Woods is another shot back in fourth, tied with a group that includes Northern Irishman Rory McIlroy (72) and Robert Karlsson of Sweden (72).
Spain's Sergio Garcia (69), Ireland's Padraig Harrington (69) and South Africa's Charl Schwartzel (70) were at 140.
McIlroy's round was marred by a two-shot penalty for brushing away sand in front of his ball, which sat on the fringe on the ninth. Meanwhile, fourth-ranked Martin Kaymer (73) failed to make the cut in a tournament he has won three times. Meanwhile, a relatively unknown 22-year-old Dane surged into the lead of the star-studded tournament in a bid to win his first event on the European Tour.
Much of the attention was on Woods, who is trying to follow up his season-ending victory at the Chevron World Challenge with another win. The Chevron success ended a two-year run without a victory, a period in which the 14-time major winner endured a series of injuries and turmoil in his personal life.
Woods had a bogey-free first round but admitted the greens fooled him much of the day. He seemed to sort them out on Friday, making several key putts including a 10-footer for his final birdie on the 15th.
But he said players "were grinding along" and that it was anyone's tournament to win with the leaderboard featuring nine players within two shots of Olesen.
Woods is optimistic the changes in his swing instituted by new coach Sean Foley are paying off.
"Certainly I have much more experience within the system, and I've grown to understand what Sean wants me to do and how my body is going to do those things and produce the numbers he wants me to produce," Woods said. "If you would have asked me (six to eight months ago) if I would understand the system as well as I do and the numbers I'm producing, I probably would have said no ... Now I do and when we talk, it's very simple."
While Woods was the picture of consistency Friday, the big-hitting McIlroy took fans on a rollercoaster ride after holding a share of the lead after the first round.
The 22-year-old U.S. Open champion, playing with Woods for a second day, opened with a bogey and double bogey after an errant drive and some shaky putting. He rallied with three birdies before a double bogey on the ninth. That's where he got a two-shot penalty for brushing away the sand in front of his ball. Playing partner Luke Donald (72) spotted the infraction and called him on it.
rather than get rattled, McIlroy produced two birdies on the next three holes to end at even par.
"Obviously, that wasn't the best start, 3 over through three. I battled back really well to get it back to even par after eight," McIlroy said. "Made a mistake on 9 when I brushed the sand off the green, wasn't thinking clearly and a penalty there. Felt like I played the back nine well. Even par, considering everything that happened out there today, is a decent score."
Players are allowed to brush away sand on the green but not on the fringe.
"I mean, my ball was just maybe six feet off the green and there was a lot of sand in between my ball and the hole. I just brushed the sand and Luke was like, 'I don't think you can brush sand off the fringe,'" he said. "And I'm like, 'Oh, yeah, you're right'. Just one of those things ... You're going to get a bad deal every now and again, and just have to take it on the chin and try and come back and get the shots back as quick as possible."
Kaymer headlined the list of 60 players to miss the cut of 2 over. The 27-year-old German, who had come in as a favorite after his past success on the course, blamed putting for his troubles.
"Expectations were very high," he said. "When you go to a tournament where you've played very well in the past, you expect you're going to be successful somehow and it hasn't happened this week. It's OK. I practiced hard in the winter and it will come together at some stage."
British Open winner Darren Clark also missed the cut after shooting a 9-over 153. Others failing to qualify for play on the weekend included Colin Montgomerie of Scotland (147), Edoardo Molinari of Italy (149), American Todd Hamilton (149) and Michael Campbell of New Zealand (149).
___
Follow Michael Casey on Twitter at https://twitter.com/mcasey1
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For the specific tasks at which microwaves excel, they?re much more efficient than stove tops and ovens.
Let?s get this out of the way right off the bat. For the specific task microwaves excel at, they?re much more efficient than stove tops and ovens. The basic stats on energy use prove this to be the case.
Skip to next paragraph Trent HammThe Simple Dollar is a blog for those of us who need both cents and sense: people fighting debt and bad spending habits while building a financially secure future and still affording a latte or two. Our busy lives are crazy enough without having to compare five hundred mutual funds ? we just want simple ways to manage our finances and save a little money.
However, the savings are relatively small. Per comparable use (one hour in the oven versus fifteen minutes on the stovetop or in the microwave), you?re saving on the order of 1 to 1.5 kW by using the microwave ? a savings of about $0.20 per hour of stovetop use, in other words.
In truth, though, the savings are bigger than that. Let?s dig in a little deeper.
The one task that microwaves really excel at is bringing water to a boil. They can do this much faster than virtually anything else in your home (except for perhaps a magnetic induction stove top, which is an incredibly expensive investment).
I can bring a few cups of water to boil in our microwave in about two minutes. On our stovetop, it takes about eight to ten minutes to bring a similar amount to a boil. That?s a savings of six to eight minutes in the middle of meal preparation, which can make a quick meal really fast and a slower meal faster. It can get our family to the dinner table earlier and allows us to have more quality family time after supper. That?s a real value for us.
Simply put, for every cup boiled in the microwave, it takes me about four minutes less time to do it than on the stovetop. It also saves approximately $0.03 doing it that way.
This simple step is something that saves both time and money. Let?s say I?m going to boil some pasta on the stovetop. I get out a large microwave-safe bowl, fill it with a significant amount of water, and microwave it. The time to bring it to a boil or near-boil in the microwave is far lower than on the stovetop, so I?m actually boiling my pasta much faster by bringing the water to boil in the microwave. I?m also saving $0.05 or so by doing it this way.
The same idea is true in almost any recipe that requires a hot or boiling liquid. It?s far more efficient to simply get cold water out of a tap or cold liquid from the refrigerator and boil it in the microwave than to use the stove top or oven.
Typically, I don?t fully cook things in the microwave. Because they excel so well at one specific thing ? raising liquids to a boil ? they?re often poor at other things, such as properly cooking a dish of food.
Thus, my usual technique is to bring the liquid to a boil in the microwave, then just transfer it to whatever I?m cooking in on the stove top or the oven.
It?s a simple little thing, really. It?s never going to make you rich, but it does save a few cents. More importantly, it saves something else ? a bit of time. Simple changes that save both time and money are valuable ones.
This post is part of a yearlong series called ?365 Ways to Live Cheap (Revisited),? in which I?m revisiting the entries from my book ?365 Ways to Live Cheap,? which is available at Amazon and at bookstores everywhere.
The Christian Science Monitor has assembled a diverse group of the best economy-related bloggers out there. Our guest bloggers are not employed or directed by the Monitor and the views expressed are the bloggers' own, as is responsibility for the content of their blogs. To contact us about a blogger, click here. To add or view a comment on a guest blog, please go to the blogger's own site by clicking on www.thesimpledollar.com.
Source: http://rss.csmonitor.com/~r/feeds/csm/~3/sBk4uk3b6Wk/Skip-the-stove-use-the-microwave
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Leukemic cutaneous T-cell lymphoma (L-CTCL) is a leukemia arising from T-cells, a type of white blood cell. This cancer can involve the skin and other organs, and patients often die within three years.
Rachael A. Clark, MD, PhD, BWH assistant professor of dermatology and associate dermatologist and Thomas Kupper, MD, BWH Department of Dermatology chairman and their colleagues now report a new study that low-dose Campath (alemtuzumab) not only treats patients with L-CTCL but does so without increasing their risk of infections.
The study was electronically published on January 18, 2012 in Science Translational Medicine.
Campath was previously believed to kill all lymphocytes (T-cells and B-cells) in the body and render patients susceptible to infections. However, Clark and Kupper found that Campath only kills T-cells that enter the bloodstream, but it spares a newly discovered population of T-cells that live long-term in the tissues.
"We noticed that our patients were not getting infections, and we looked in the skin. We saw healthy T-cells remaining there despite the fact that there were no T-cells in the blood," said Clark. "We used to believe that most T-cells responsible for protecting against infection were in the bloodstream. But we now realize that highly protective T-cells also inhabit tissues such as the skin, lungs and gastrointestinal tract. It is these tissue resident T-cells that are critical in protecting us from infection on a day-to-day basis."
By showing that Campath kills circulating T-cells, including the cancerous T-cells, but spares tissue resident T-cells, Clark and Kupper have shown that Campath effectively treats L-CTCL while sparing normal immunity. Their findings are also the first demonstration in human beings that tissue resident T-cells provide frontline immune protection of the skin.
"We're very grateful to our patients for entrusting us with their care and for teaching us important lessons about the immune system." said Clark.
In a companion piece, Mark Davis, PhD, Stanford University School of Medicine, called the work a "translational tour de force."
###
Brigham and Women's Hospital: http://www.brighamandwomens.org
Thanks to Brigham and Women's Hospital for this article.
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By Randee Dawn
Fish and visitors overstay their welcome within three days; New York-based comedian Mark Malkoff only wanted to see if he could take advantage of random celebrities' good nature by staying over at their homes for a single night.
Malkoff got 13 celebs to say "yes," including Justine Bateman, who lets him stay in her treehouse; Camryn Manheim, who lets him snooze with her Emmy; Kate Walsh, who?put on her own matching P.J.s and crawled in bed?with him (he called his wife to give her the heads-up and Walsh assures her it's OK because "I'm not attracted to him at all"); and "Bridesmaids" director Paul Feig, who gives him the patio, then refers him to Rob Corddry, who turns him down.
"You're really good, actually, at napping at celebrities' homes," Steven Weber tells him.
As Malkoff sums up, "Most celebrities with the exception of Rob Corddry are really nice people. I also learned that annoying persistence can get you a free place to crash."
OK, your turn! What celebrity would you want to have a sleepover with? (Strictly platonic, of course: They're not attracted to you at all, remember.) Tell us on Facebook.
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Foreclosure-related properties, which made up roughly one in five home sales in the third quarter of last year, sold for an average 34 percent less than homes that were not ?distressed sales,? new data show.
Source: http://www.msnbc.msn.com/id/3036697/vp/46138701#46138701
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Contact: Cathia Falvey
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New Rochelle, NYMary Ann Liebert, Inc. announces the launch of its new website, offering streamlined access to over 92,000 articles from 70 high-impact publications. Using the latest technology, LiebertPub.com introduces an intuitive interface that helps users discover content quickly and easily, as well as new tools to help librarians manage access.
"With the launch of the new LiebertPub.com, we continue our commitment to support scientific innovation by providing the latest technology-enabled content and solutions," said Mary Ann Liebert, CEO and Publisher. "We are proud to offer our users a cutting-edge platform that offers tools for collaboration and discovery."
The new interface offers users multiple ways to navigate through the site, including enhanced search functionality and reference linking. Personalization options include RSS feeds, favorites lists, customized content alerts, and citation tracking. References can be downloaded to citation managers. Social features allow readers to recommend articles through CiteULike, Twitter, and other social media.
For libraries, the new site offers an updated Librarian Resource Center with instant access to holdings lists, COUNTER 3 compliant usage statistics and SUSHI access, logo upload, link resolution configuration, and downloadable MARC records for inclusion in OPACs. The site offers multiple authentication methods including Shibboleth, and IP access.
Mary Ann Liebert, Inc.'s flagship publication, Genetic Engineering & Biotechnology News (GEN), is now fully integrated on the LiebertPub.com online platform, offering COUNTER 3 compliant usage data, unlimited simultaneous access, and seamless content discovery across the company's leading biotechnology portfolio.
For a full description of features, benefits, and content, visit our website at www.liebertpub.com.
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Mary Ann Liebert, Inc. is a privately held, fully integrated media company universally acknowledged for publishing authoritative peer-reviewed journals in the most promising areas of biomedical research, the life sciences, medicine, surgery, and public health. Mary Ann Liebert, Inc. publications continue to make critical contributions in advancing research and facilitating collaboration throughout the world in academia, industry, and government, and are also highly respected resources for legislators, policy makers, and educators. The firm publishes more than 70 journals, books, and news magazines. A complete list is available on our website at www.liebertpub.com.
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Contact: Cathia Falvey
cfalvey@liebertpub.com
914-740-2100
Mary Ann Liebert, Inc./Genetic Engineering News
New Rochelle, NYMary Ann Liebert, Inc. announces the launch of its new website, offering streamlined access to over 92,000 articles from 70 high-impact publications. Using the latest technology, LiebertPub.com introduces an intuitive interface that helps users discover content quickly and easily, as well as new tools to help librarians manage access.
"With the launch of the new LiebertPub.com, we continue our commitment to support scientific innovation by providing the latest technology-enabled content and solutions," said Mary Ann Liebert, CEO and Publisher. "We are proud to offer our users a cutting-edge platform that offers tools for collaboration and discovery."
The new interface offers users multiple ways to navigate through the site, including enhanced search functionality and reference linking. Personalization options include RSS feeds, favorites lists, customized content alerts, and citation tracking. References can be downloaded to citation managers. Social features allow readers to recommend articles through CiteULike, Twitter, and other social media.
For libraries, the new site offers an updated Librarian Resource Center with instant access to holdings lists, COUNTER 3 compliant usage statistics and SUSHI access, logo upload, link resolution configuration, and downloadable MARC records for inclusion in OPACs. The site offers multiple authentication methods including Shibboleth, and IP access.
Mary Ann Liebert, Inc.'s flagship publication, Genetic Engineering & Biotechnology News (GEN), is now fully integrated on the LiebertPub.com online platform, offering COUNTER 3 compliant usage data, unlimited simultaneous access, and seamless content discovery across the company's leading biotechnology portfolio.
For a full description of features, benefits, and content, visit our website at www.liebertpub.com.
###
Mary Ann Liebert, Inc. is a privately held, fully integrated media company universally acknowledged for publishing authoritative peer-reviewed journals in the most promising areas of biomedical research, the life sciences, medicine, surgery, and public health. Mary Ann Liebert, Inc. publications continue to make critical contributions in advancing research and facilitating collaboration throughout the world in academia, industry, and government, and are also highly respected resources for legislators, policy makers, and educators. The firm publishes more than 70 journals, books, and news magazines. A complete list is available on our website at www.liebertpub.com.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2012-01/mali-mal012612.php
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